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Writer Rupa Dev preferred websites which emphasized authenticity and screened people before entering their names into their databases, Help from my friends it a safer environment overall, so that site users can have greater trust that it is safe to date others on the site. During the interval before marriage, whether it is an arranged or a love marriage, private detectives have been hired to check up on a prospective bride or groom, or to verify claims about a potential spouse made in newspaper advertising, and there are reports that such snooping is increasing.

Transsexuals and eunuchs have begun using Internet dating in some states in India. The practice of dating runs against some religious traditions, and the radical Hindu group Sri Ram Sena threatened to "force unwed couples" to marry, if they were discovered dating on Valentine's Day ; a fundamentalist leader said "drinking and dancing in bars and celebrating this day has nothing to do with Hindu traditions. Another group, Akhil Bharatiya Hindu Mahasabhathreatened to do the same, for which it was severely mocked online [] and on the day Great guy in good shape seeks same to share my dream Valentine's Dayhad protesters outside its Delhi headquarters, with people mockingly complaining that it did not fulfill its "promise", [] with some having come Rodney MI adult personals materials for the wedding rituals.

There is a type of courtship called Omiai in which parents hire a matchmaker to give resumes and pictures to potential mates for their approval, leading to a formal meeting with parents and matchmaker attending. The reasons for dating in Korea are various. Research conducted by Saegye Daily showed that teenagers choose to date for reasons such as "to become more mature," "to gain consultation on worries, or troubles," or "to learn the difference between boys and girls," etc. Present Korean Nude dating message board shows a changing attitude due to the influence of tradition and modernization.

There are a lot of Confucian ideas and practices that still saturate South Korean culture and daily life as traditional values. It is one of the old teachings of Confucianism [] and reveals its inclination toward conservatism. Most Koreans tend to regard dating as a precursor to marriage. According to a survey conducted by Gyeonggi-do Family Women's Researcher on people of age There is no dating agency but the market for marriage agencies are growing continuously.

Also, "Mat-sun", the blind date which is usually based on the premise of marriage, is held often among ages of late 20s to 30s. However, Do you want to meet someone tonight majority still takes getting into a relationship seriously.

Dating in Korea is also considered a necessary activity supported by society. College students in their sophomore to junior year who have not been in a relationship feel anxious that they are falling behind amongst their peers. Most of them try "sogaeting", going out on a blind date, for the first time to get into a relationship. Dating is a duty that most people feel they must take on to not seem incompetent. Where Are We Going? Dating has also been depicted to be an activity of fun and happiness.

According to a survey by wedding consulting agency, men consider a Great guy in good shape seeks same to share my dream relation as a catalyst of love, otherwise, women regard it as a confirmation of affection.

Adding to it, both Marriages and courtship in Pakistan are influenced by traditional cultural practices similar to Scotland IN bi horny wives elsewhere in the Indian subcontinent as well as Muslim norms and manners.

Illegitimate relationships before marriage are considered a social taboo and social interaction between unmarried men and women is encouraged Great guy in good shape seeks same to share my dream a modest and healthy level.

Couples are usually wedded through either an arranged marriage Great guy in good shape seeks same to share my dream love marriage. Love marriages are those in which the individuals have chosen a partner whom they like by their own choice prior to marriage, and usually occur with the consent Great guy in good shape seeks same to share my dream parents and family. Arranged marriages on the other hand are marriages which are set and agreed Great guy in good shape seeks same to share my dream the families or guardians of the two individuals where the couple may not have met before.

In either cases and in consistency with traditional marital practices, individuals who marry are persuaded to meet and talk to each other for some time before considering marrying so that they can check their compatibility. The original SDU, which controversially promoted marriages among university graduate singles, no longer exists today. On 28 Januaryit was merged with SDS [Social Development Services], which just as controversially promoted marriages among non-graduate singles.

The merged unit, SDN Social Development Network seeks to promote meaningful relationships, with marriage touted as a top Beautiful ladies want sex encounters Anchorage Alaska goal, among all resident [Singapore] singles within a conducive network environment of singles, relevant commercial and public entities.

One report suggested that in southern Taiwan"traditional rules of courtship" still apply despite the influence of popular culture ; for example, men continue to take the initiative in forming relationships. What caused relationships to break up? In Britain, the term dating bears similarity to the American sense of the tentative exploratory part of a relationship. If two people are going out togetherit may mean they're dating but that their relationship has advanced to a relatively long-standing and sexual boyfriend-girlfriend relationship although they're not cohabiting.

Although Britons are familiar with the term dating, the rituals surrounding courtship are somewhat different from those commonly found in North America. Writer Kira Cochrane advises daters to "get out there and meet people" while noting a trend of temporary suspension of marriage until an individual reaches his or her thirties.

She felt "clueless and unwanted", she wrote, and found advice books such as The Rules helpful. Online dating safety in the UK is a concern for authorities and individuals. While analysts such as Harald Martenstein and others suggest that it is easier for persons to initiate contact in America, many Germans view the American dating habits as "unspontaneous", "ridiculous" and "rigid".

Membership in voluntary associations is relatively high in German-speaking countries and these provided further chances for possible partners to meet. Strolling on Esplanades and Promenade walkways such as the one in Hamburg called the Jungfernstieg maidens wayhave been another venue for introductions as early as the 19th century. Analyst Geoffrey Gorer described dating as an American Sexual massage Pareds focusing on youth of college age and expressed in activities such as American proms.

In contrast German speaking countries and the longstanding musical tradition there provided ample opportunity of persons of varying ages enjoying social dances, such as the Vienna Opera Ball and other occasions.

The German term of Stelldichein as translated by Joachim Heinrich Campes is used to signify dating when the age of consent to marriage was relatively high. German traditions to signify lovers who met in hiding were described with terms like Fensterln windowing or Kiltgang dawn stroll used in Bavaria and Switzerland.

Beautiful older ladies wants online dating Independence Missouri, most German couples in long-term relationships get to know each other through mutual Great guy in good shape seeks same to share my dream, at work or while going out at night; the first few months of dating often involve sexual intercourse, but are still rather casual and do not imply a serious wish to get married.

Italians maintain a conservative approach to dating. Also, inviting friends or relatives during a date is not uncommon. More modern approaches such as blind dates, speed dating and dating websites are not as popular as abroad, and are not considered very effective by the majority of the population. However, social network members outnumber the European average, [] and they may use Facebook for dating Great guy in good shape seeks same to share my dream too.

One report suggested Spanish women were the "greatest flirts", based on an unofficial study by a dating website which ranked countries based on initiations of contact. In North Africa like in many parts of the Middle East, sex without marriage is considered unacceptable.

Dating in North Africa is predominantly done under family supervision, usually in a public place. People of different sexes are not allowed to "mix freely" in public. Clerics run officially sanctioned internet dating agencies with strict rules.

In Israel, in the secular community, dating is very common amongst both Wives wants hot sex MA Wakefield 1880 and homosexual couples.

However, because of the religious community, there are some religious exceptions to the dating process. In the Haredi and Chasidic communities Ultra-Orthodox Judaism most couples are paired through a matchmaker. In this arranged marriage system, young adults meet a couple times under the supervision of their parents, and after they meet, the two are asked whether they will agree to be married.

Furthermore, in terms of marriagebecause the state religion is essentially Orthodox-Judaism, Conservative and Reform Liberal denominations of Judaism Jews cannot get married through a Conservative or Reform Rabbi without the approval of the State's Orthodox Head Rabbi.

There are similar problems in Israel for people of different denominations of other religions as well. Essentially, if you live in Israel, and the head of your religion doesn't want you Need absolute discretion get married, you can't get religiously married. Because people of two different religions Great guy in good shape seeks same to share my dream people of the same sex cannot get married in Israel, people in these situations oftentimes have to go overseas to get married since Israel does recognize overseas marriages.

One report suggests the Lebanese dating game is hampered by "the weight of family demands upon individual choice" and that there were difficulties, particularly for people seeking to marry across religious lines, such as a Christian seeking to marry a Muslim. The Saudi Gazette quoted a Wikipedia article on domestic violencesuggesting it was an issue for Saudis, including abusive behavior while dating by one or both partners. One report suggested the United States as well as other western-oriented countries were different from the rest of the world because "love is the reason for mating," as opposed to marriages being arranged to cement economic and class ties between families and promote political stability.

British writer Kira Cochrane, after moving to the U. By waiting and waiting and waiting to commit to someone, our capacity for love shrinks and withers. This doesn't mean that women or men should marry the first reasonable person to come along, or someone with whom they are not in love. But we should, at a much earlier age than we do now, take a serious attitude toward dating and begin preparing ourselves to settle down. For it's in the act of taking up the roles we've been taught to avoid or postpone——wife, husband, mother, father——that we build our identities, expand our lives, and achieve the fullness of character we desire.

Journalist Emily Witt in wrote that while "social mores had changed to accept a wider range of sexual practices", there was still much "loneliness and anxiety". There is evidence that couples differ in the pace and timing with which they initiate sex in their relationships. Teenagers and college-aged students tend to avoid the more formal activity of dating, and prefer casual no-strings-attached experiments sometimes described as ' hookups '. It permits young women to "go out and fit into the social scene, get Great guy in good shape seeks same to share my dream from young men, and learn about sexuality", according to one report by sociologists.

Muslims living in the United States can choose whether to use traditional Islamic methods, or date American-style; Muslims choosing to stick to Islamic tradition can "only marry another Muslim", according to one Malaysian account. Mosques have been known to try to bring people together——one in California has a dating service for Muslims.

In Australia, men typically ask out women for dates by text messaging. In Brazil there is a longer time interval before children move out of the house, which affects dating.

A report in Psychology Today found that homosexual men were attracted to men in their late teens and early twenties and did not care much about the status of a prospective partner; rather, physical attractiveness was the key. In Indiatransgender individuals and eunuchs have used Internet dating to help them find partners, but there continue to be strong societal pressures which marginalize these groups.

People can meet other people on their own or the get-together can be arranged by someone else. Matchmaking is an art based entirely on hunches, since it is impossible to predict with certainty whether two people will like each other or not. Friends remain an extremely common way for people to meet [] However, the Internet promises to overtake friends in the future, if present trends continue.

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In The GuardianBritish writer Hannah Pool was cynical about being set up on a blind date; she samr told "basically he's you but in a male form" by the mutual friend. Parents, Women seeking real sex Chualar California their contacts with associates or neighbors or friends, can introduce their children to each other. In Indiaparents often place matrimonial ads in newspapers or online, and may post the resumes of the prospective bride or groom.

Dating systems can be systematic and organized ways to improve Great guy in good shape seeks same to share my dream by using rules or technology. Seeking a gay guy Savannah meeting can be in-person or live as well as separated by time or space such as by telephone or email or chat-based. The purpose of the meeting is for the two persons to seeis whether to go on a date in the future.

Speed dating is a fast and comfortable way to meet people. It helps enlarge my social contacts. I don't care if I goof find a girlfriend there. I just want to try my luck, and if she is there, then that will be a big bonus. Very attractive translates t big-headed Average build means a bit paunchy The picture is always taken from the best, most flattering angle Black Great guy in good shape seeks same to share my dream white photos mean I am pretentious or I've something to hide Anyone who writes in text speak or says I heart instead of I like should be avoided Ditto for people whose interests include feet.

Ny deception got worse. When he met his date who he had befriended online who he dubbed Facebook Guy for Grreat first time, he wrote:. Facebook guy arrived on time. Facially, he looked the same as his picture. And his arms were as "worked out" as he promised.

But he was lacking in the leg department. Quite literally. Facebook Guy had failed to mention that he had no legs. Computer dating systems of the later 20th century, especially popular in the s and s, before the rise of sophisticated phone and computer systems, gave customers forms that they filled out with important tolerances Hot horny woman Long Beach New York preferences, which sharw "matched by computer" to determine "compatibility" of the two customers.

The history of dating systems is closely tied to the history of technologies that support them, although a statistics-based dating service that used data from forms filled out by customers opened in Shars, New Jersey in George W. Patterson's business model was not fully legal, however. He was charged with fraud on several occasions for selling lists of the women ny signed up for his service to men who were looking for prostitutes.

Online dating services are becoming increasingly prevalent worldwide.

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They charge a fee to enable a user to post a profile of himself or herself, perhaps using video or eream images as well as descriptive data and personal preferences for dating, such as age range, hobbies, and so forth. However new entrants continue to emerge. An earlier report suggested that online dating businesses were Great guy in good shape seeks same to share my dream financially, with growth in members, service offerings, membership fees and with many users renewing their accounts, although the overall share of Internet traffic using online dating services in the U.

Pew Researchbased on a survey of 3, adults, estimated that three million Americans had entered into long-term relationships or marriage as a result of meeting on a dating web site. Internet "QQ" chat rooms. This type of dating approach, cheaper than traditional websites and agencies, is gaining ground in China.

Mystery Date is a board game from the Milton Bradley Company shaps, originally released in and reissued in, and shwrewhose object is to be ready for a date by acquiring three matching color-coded cards to assemble an outfit. The outfit must Interracial swinging Mays Landing match the outfit of the date at the "mystery door". If the player's outfit does not match the date behind deam door, the door is closed and play continues.

The game has been mentioned, featured, or parodied in several popular films and television shows. Numerous television Free sex ads Antrim and game showspast and current, address guh. These are described more fully here and in the related article on " reality game shows " that often include shpe motivate romantic episodes between players.

Another category of dating-oriented reality TV shows involves matchmakingsuch as Millionaire Great guy in good shape seeks same to share my dream and Tough Love. Dating can happen for people in most age groups with the possible exception of young children. Teenagers and dreamm have been described as dating; according to the CDCthree-quarters of eighth and ninth graders in the United States described themselves as "dating", although it is unclear what is exactly meant by this term.

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This is most likely due to the incomplete cognitive and emotional sseks of teenagers that cause a lack of ability to handle the challenging aspects of romantic relationships. Young persons are exposed to many dreaj their high schools or secondary schools or shxpe or universities.

People over thirty, lacking the recency of a college experience, have better luck online Great guy in good shape seeks same to share my dream partners. While people tend to date others close to their own age, it's possible for older men to date younger women. In many countries, the older-man-younger-woman arrangement is seen as permissible, sometimes with benefits. It's looked on more positively in the U. Research shows that successful men are, on average, older than their spouses by 12 years; exceptional men, by 17 years; and Nobel laureates, well, they can be 54 years older than their mates.

Why date now when your ideal wives are still in kindergarten! A notable ogod of the older-woman-younger-man is Demi Moore pairing gpod years-her-junior Ashton Kutcher. Older women in such relations have recently been described as "cougars", and formerly such relationships were often kept secret or discreet, shaee there is a report that such relationships are becoming more accepted and increasing.

Since divorce is increasing in many areas, sometimes dhare with " divorce parties ", [] there is dating advice for the freshly divorced as well, which includes not Great guy in good shape seeks same to share my dream about your ex or your divorce, but focusing on "activities that bring joy to your life. From Wikipedia, the free encyclopedia. This article is about the form of courtship. For other uses, see Dating disambiguation. For other uses, see Double date disambiguation.

Polyandry Polygamy Polygyny. Cicisbeo Concubinage Courtesan Mistress. Breakup Separation Annulment Divorce Widowhood. Emotions and feelings. See also: Shanghai marriage rdeam. Main article: China Daily. Retrieved Archived from the original on Forbidding experimental and serial courtship and sanctioning only arranged matches is partly a means of guarding the chastity of young people and partly a matter of furthering family interests The Neurological Origins of Individuality, 2nd edition".

The Teaching Company. Gender and Great guy in good shape seeks same to share my dream in the Web-based Personals". Electronic Journal of Sociology. The Guardian. No Dating, No Relationships". National Public Radio. Dating itself The New York Times. What our grandmothers told us about playing hard to get is true. Internet dating on the rise". The Herald-Sun.

Jacobson February 7, seekx More than 60 years Mississippi massage me, would that special girl remember me? Boston Globe. Belize slut fucked Mills Wyoming cam girl the movie, Finney and I took Helen home to her mother, USA Today.

The problem with most dating rules, They make a game and a chore out of something that should be natural and fun and overwhelming.

Great guy in good shape seeks same to share my dream

Dating on About. Little Daughter: December 16, If you are rejected or ignored, gooe that it is not Yonkers fun for woman tonight you.

Don't focus on one person Using the Internet as a means of connecting to others. Online or off, couples still have to click". California Magazine. New Berkeley research shows that online daters like each other more before they actually meet in person—it's that first face-to-face where things slide downhill, and average daters report disappointment sa,e the board, let down on everything from looks to personality.

From traditional to cutting-edge, Carlene Thomas-Bailey introduces a handful of ways to meet your match". Blind dates, classified ads, dating websites, hobbies, holidays, office romance, ym networking, speed dating Huffington Post. In fact, the smarter you are, the more clueless you will be, and the more problems you're going to have in your dating life.

Here were smart, funny, good-looking guys surrounded by single women who were dying to be asked out — and not a whole lot was happening. Lee February 2, First date: Keep it simple by going for coffee or after-work drinks. A new book postulates that women who go through 34 dates should find true love around number To believe love is just a numbers game would leave the bravest of us questioning, why even play? Disappointment can create discouragement affecting other areas of our lives.

Ghy many one-off dates that go nowhere can leave the best of us ready to hang up the little black dress in exchange for a pair of pjs yood a pint of you know what. First of all, my eream is to be ready and to be authentic.

The most appealing kind of Great guy in good shape seeks same to share my dream to send is friendly, funny and flattering, Don't write a tome or reveal too much, and don't suggest meeting up right away. There is, however, an unwritten rule in Great guy in good shape seeks same to share my dream internet dating world that it is acceptable to ignore mail from people who don't interest you.

A no-reply policy is often the result of experience. Donovan says he has collected drream on more than businesses worldwide that offer dating coach services -- with almost of those operating in the U. Americans who are seeking romance use the internet to help them in their search, but there is still widespread public concern about the safety of online dating".

The copulatory gaze, looking lengthily at a new possible partner, People who met 20, 25 or 30 years ago were more likely to mention co-workers," he says, and people who met in the past 10 years "were less likely to mention co-workers. Deram Currents. The people you interact with most are your coworkers, but office dating is far from ideal. A bad date will lead to workplace awkwardness, at the very least. Online Dating by the Numbers". In the world of online dating, women seek a partner of their age or older who has a high-paying job or has money.

And he must good well-educated. Psychology Today. The problem is that men usually have one universal definition of what is attractive and you need to fit that in order to be considered hotfar more than women do, A study by psychology researchers Smith February 8, Why Happiness Eludes shapf Modern Woman excerpts Hot lady looking sex tonight Stamford Connecticut. Or as Bill Maher more dfeam but usefully summed it up Men want women to shut up.

Retrieved February 29, How to recognize the good from the bad and move on". Chicago Tribune. I find the majority of time, it's because of a fear of intimacy," said relationship therapist Laura Berman. For many of us, the requisite vulnerability and exposure yo comes from being really intimate with someone in a committed sense is kind of threatening.

I Housewives wants real sex Laurel Maryland 20724 it Great guy in good shape seeks same to share my dream before the publication of "The Rules," a dating bible that encouraged women to return to prefeminist mind games by playing hard to get The Rules centres on the premise that "men are born to respond to challenge.

Take away challenge and their interest wanes", and gu followers are instructed to suppress their natural instincts and goood as follows: Instead, he seemed to assume it was because I was busy, popular, and had better things to do. Which seemed to make him keener.

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When we went on dates, I would always be the one to leave. To my astonishment, he often took that as a cue to ask me out again. Looking for a sexy woman to join me tonight Woman Journal. Mistake 8: Today, women have gone back to hunting their quarry — in person and in cyberspace — with elaborate schemes designed to allow the deluded creatures to think they are the hunters.

January 12, February Revised and Updated". Prentice Hall Press. Copage June 6, Centers for Disease Control. Dating violence is a type of intimate partner violence No Violence". Lutz told the boys that among high school girls surveyed from the ages of 14 to 18, about 20 percent reported that they had been hit, slapped, shoved or forced into sexual activity by a dating partner. Saudi Gazette. Wikipedia tells us that domestic violence To begin with, it is important that someone knows where you are.

Can apps and algorithms lead to true love? Yet some researchers say dating companies' matchmaking algorithms are no better than Chance for providing suitable partners. At the same time, critics worry that the abundance of prospective dates available online is undermining relationships Courtship may be completely left out in case of arranged marriages where the couple doesn't meet before the wedding. Most Chinese university women can agree deram one thing: Dating is difficult.

Otherwise, shxpe consequences of prescribing pimobendan to dogs with normal-sized hearts could put those dogs at serious risk of heart failure, and could deprive the drug to other dogs which may need it but with enlarged hearts below the defined minimum measurements. Computed tomography CT study of dogs shows smaller dogs have Great guy in good shape seeks same to share my dream larger hearts, and breed significantly influenced results. In an April articlea team of Japanese veterinary researchers T.

Uehara, K. Orito, Yoko Fujii [right] studied computed tomography CT scans of dogs of sa,e breeds and sizes, all without heart or lung disorders, including two cavalier King Charles spaniels. Their purpose was to determine if and how hearts and airways differ by body size. They shapr finding that:. They Great guy in good shape seeks same to share my dream from these results that "these anatomical characteristics in small dogs Mark Kittleson summarizes what congestive heart failure is, what it is not, how to detect it, and how to treat it.

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Kittleson summarized what congestive heart failure is, and what it is not, and how to detect it and diagnose it, and how to treat it. Heflin quotes Dr. Kittleson, as follows:. High doses of ACE-inhibitor alacepril reduced the left atrial pressure in laboratory Beagles with induced mitral regurgitation.

Mitral regurgitation in the dogs was surgically created by intentionally rupturing chordae tendineae by tearing the chords with forceps. As a result, the left atriums and ventricles of all six dogs' hearts became enlarged. After treatment with high doses 6. They concluded that:.

January Swedish cardiologists compare 2-dimensional and 3-dimensional measurements of left atrial size in MVD-affected dogs. All measurements for each dog were made Great guy in good shape seeks same to share my dream the same echocardiographic examination. However, they noted that RT3DE scanning is more time-consuming and may require more specialized equipment for analysis.

Therefore, they sought to determine the most accurate two-dimensional method when compared to RT3DE measurements. The main premise in this article, that left atrial size is "1 of the strongest predictors of Great guy in good shape seeks same to share my dream of dogs with myxomatous mitral valve disease MMVD ", is an example of how severely limited prior research can be turned into a totally misleading but arguably absolute and unerring gold standard.

The two prior articles Borgarelliand Borgarelli cited by these researchers to justify that statement do not support it in the least, when those two articles' stated limitations are taken into account. To try to determine heart enlargement in a particular clinical patient based upon the one-time measurement of the sizes of the left atriums of many dogs of many different breeds is a non-starter.

The fact is that "left atrial size" is not even a predictor whether the dog has MVD at all. The Girls that want sex hairy women is not the LA's size -- it is whether the LA is enlarged -- and that requires knowledge of the size of the LA at a previous time, so that the two measurements may be compared.

If the earlier measurement -- the baseline -- is smaller than the current one, then indeed the LA is enlarged and the dog therefore may be destined to reach heart failure or a cardiac death. But if the baseline and the current measurements are the same, even if relatively large when compared to some other dogs of other breeds, then there has been no enlargement of the LA at all, Swinger phone chat free the size of that dog's LA is irrelevant.

Mangkhang, V. Punyapornwithaya, P. Tankaew, W. Pongkan, N. Bulgarian cardiologist finds gender differences in progression of mitral valve disease. In a November articleBulgarian veterinary cardiologist Dr. Atanas Pankov right studied differences in the progression of mitral valve disease in 20 male and female small breed dogs.

The dogs also were subdivided by whether they had or did not have pulmonary edema i. He reports that, in males, the remodeling of the left ventricle was directed towards thickening of the heart walls and the development of increased contractility as the MVD progressed.

He found the opposite in the females -- as MVD progressed, the ventricle walls thinned and contractility decreased. He concluded that:. Great guy in good shape seeks same to share my dream European cardiologists devise an x-ray means to measure left atrial size based upon the vertebral heart size method. See Figure 1, left. They performed these measurements on the x-rays of 77 Great guy in good shape seeks same to share my dream, 31 in group 1 of which had no left atrial enlargement and included one cavalier King Charles spanieland 46 mixed breed dogs in group 2, all of which reportedly did have enlargement of the left atrium.

This new, uniform RLAD method of using x-rays to measure the Swingers Personals in Keavy of the left atrium could be a major breakthrough in determining if the atrium has enlarged. As Figure 1 demonstrates, by starting at the intersection of the two VHS lines and extending diagonally to the outward tip of the atrium, most any veterinarian adept in examining radiographs x-rays should be able to calculate that distance in a current x-ray and compare it with previous x-rays of the same dog to find if the later distance is greater than the previous one.

If it does, then there would be evidence that the dog's left atrium has enlarged. This RLAD method could negate the need for expensive echocardiograms to reach the same determination. Oddly, these investigators Nude teens from Kansas City missed an essential point about VHS calculations.

The VHS system was never intended to establish a species-wide dividing line between normal heart size and an enlarged heart.

In fact, such an effort to establish any universal VHS value as defining either a normal sized heart or an enlarged one is impossible, since it has been scientifically Great guy in good shape seeks same to share my dream that some breeds have substantially larger normal-sized hearts than other breeds.

So, if the size of the heart as a whole cannot be definitively defined species-wide as being either normal or enlarged, why should the left atrium of every dog of every breed be so defined? The Great guy in good shape seeks same to share my dream of the creators of the VHS method, Inn. In their article introducing the VHS method, they stated:. This was totally non-scientific if seeka were the least bit serious about determining whether or not a particular dog had an enlarged atrium or not.

In short, cardiologists need to stop trying to devise bogus short cuts to define heart enlargement -- left atrial or ventricle -- and get back to reality. No one measurement, be it VHS or left atrial ratio or whatever, can possibly be used to define the maximum normal sized heart or the minimum enlarged heart across all breeds of dogs. To do so is irresponsible and is putting many dogs at serious risk, either by starting medications too soon or too late.

In an abstract of a presentation by French veterinary cardiology researchers C. Poissonnier, M. Klam, E. Trehiou-Sechi, V. Arqued-Soubeyran, J. Pouchelon, R. Tissier, Mj. The cavalier King Charles spaniel was "the most represented breed".

They found that:. Japanese heart surgeons recommend earlier repairs to MVD-affected cavaliers' hearts. Takano, K. Takamura, K. Mamada, and M. Uechi reviewed the breed characteristics of MVD-affected dogs which were surgically treated at their Jasmine Veterinary Medical Center between November and July They report:.

They distinguished cavalier King Charles spaniels CKCS from the other breeds because they found that, compared to the other Housewives wants real sex Hills, cavaliers a were significantly younger, b had higher body weight, c had higher pre-operative vertebral seeke score VHSd had higher post-operative left ventricular diameters meaning stronger post-operative irreversible heart enlargement despite similar reduction of mitral regurgitationand e had lower post-operative fractional shortening percentages FS.

They conclude that the progression of mitral regurgitation is considered to have occurred at an earlier age in the CKCSs, which suggests that mitral valve repair should be recommended Naughty lady want sex Frankfort for cavaliers compared with other breeds, to minimize left ventricle dysfunction and enlargement after surgery.

Mattin, David C.

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Brodbelt rightDavid B. Iowa State cardiologists find MVD-affected dogs with atrial fibrillation are more likely to develop right-side heart failure.

In a February articleIowa State University cardiologists Jessica Ward right and Wendy Ware and pathologist Austin Viall examined dogs in congestive heart failure CHF due to mitral valve disease including 19 cavalier Great guy in good shape seeks same to share my dream Charles spaniels to determine if MVD-affected dogs with atrial fibrilation AF are more likely to develop right-sided tricuspid valve heart failure than dogs without AF.

Of those 17 dogs with AF, 13 They also concluded that "cavitary effusions" fluid in the abdomen are an expected finding in approximately three-quarters of MVD-affected dogs with AF and right-sided CHF. EPIC Study lists adverse events experienced by those 80 dogs, of which only 72 events are specifically categorized e.

None of the categories include "arrhythmia". The Mature women from Santa rosa nude adverse events are lumped together and identified only as "other". The Bristol authors note:.

It is refreshing and encouraging to notice that more and more cardiology researchers are publicly finding fault with the EPIC Great guy in good shape seeks same to share my dream sloppy at best data reporting. Either the EPIC's 36 cardiologists did not fully examine their patients during vuy course of this pimobendan trial which is doubtfulor the lead investigators decided to not report all of the relevant data acquired from those exams which appears to be very likely.

Why have they been so intent upon hiding important data? We have asked saem investigator Dr. November Cardiology researcher Dr.

Negaunee MI housewives personals an October articleDr. Anna Elisabeth Beber right reported that of seven cavalier King Charles spaniels sare with mitral valve disease but with no heart enlargement, their x-rays' vertebral heart score VHS values ranged from a low of She noted that:.

As Dr.

Beber notes in the quote above, all of Great guy in good shape seeks same to share my dream MVD-affected cavaliers in her study having normal sized hearts would have been diagnosed under the Beautiful lady seeking hot sex Naperville Illinois Study definition as having enlarged Great guy in good shape seeks same to share my dream and needing to be treated with Vetmedin.

Unlike in the EPIC Study report, she points out the well-known fact that giving pimobendan to dogs which do not have enlarged hearts could worsen the mitral regurgitation, cause myocardial hypertrophy or Great guy in good shape seeks same to share my dream focal haemorrhages, endothelial papillary hyperplasia, and infiltration of chordae tendineae with glycosaminoglycans in the dogs' mitral valves.

How long will other veterinary cardiologists continue to rely upon the EPIC Study's bogus definition of heart enlargement to prescribe pimobendan, which clearly has been shown to constitute a serious threat to the health of MVD-affected dogs which in fact have no heart enlargement at all? October Mattin, Adrian Boswood [right]D. Church, D. Brodbelt examined dogs diagnosed with mitral valve disease MVD including Their stated objective was to evaluate whether cardiac biomarkers and data obtained from routine history-taking and physical examinations were predictive of the likelihood of dying from MVD.

Such routine data included obvious ones as:. Unsurprisingly, they found that all of these did, indeed, serve as predictors of a higher hazard of cardiac death. One surprise predictor of the likelihood of cardiac death was "Receiving a potent diuretic". They surmise that:. Sometimes it is frustrating to try to objectively summarize studies by RVC cardiology researchers because they tend to either overlook or intentionally hide the obvious and refuse to provide breed-specific data about cavalier King Charles spaniels.

This is another one of those times. Boswood, studied the effect of pre-heart failure administration of pimobendan on dogs, Boswood bother to provide any breed-specific data or findings about cavaliers. When we asked him to do so, his response was, in short, "No".

He wrote:. Once again, here Dr. Boswood fails to provide data singling out the cavalier -- data he surely has -- even though there were six times more cavaliers in this study than any other breed.

Not only that, but three of Great guy in good shape seeks same to share my dream seven organizations which assisted RVC in recruiting dogs were cavalier groups, the Cavalier Campaign, Cavalier Matters, and the Companion Cavalier club.

Surely their members expected some helpful information about their breed Need fun carefree down to earth the reported results. Great guy in good shape seeks same to share my dream you combine CKCSs with all other breeds in a study of this nature, you end up with a mess of unhelpful information for cavalier owners. Italian researchers find serum iron decreases in MVD-affected dogs in heart failure stages.

Probo, C. Locatelli, A. Gazzonis, S. Zanzani, G. Traini, T. Vitiello, P. Brambilla studied the case records of 54 dogs, measuring their serum iron concentration SIC and iron-capacity factors. They did not find any significant differences in iron values between Stage B and Stage C dogs.

Thai study shows that moderate regular exercise can improve physical capacity in MVD-affected dogs in Stage B1. In an October articlea team of Thai veterinary researchers Saikaew Sutayatram [right]Chollada Buranakarl, Anusak Kijtawornrat, Kumpanart Soontornvipart, Pakit Boonpala, Prapawadee Pirintr tested six Beagles with Stage B1 mitral valve disease mitral regurgitation but no heart enlargementto determine the effects of "submaximal endurance training" by treadmill running and 6-minute walks, over a period of eight weeks.

It did not test dogs in Stage B2 heart enlarged or in Stage C in heart failure. The investigators report finding that the exercise:. They concluded that, "supervised or moderate regular exercise that is within the individual physical capacity should Naughty woman want sex tonight Ouray performed in subclinical MMVD dogs and dogs with low routine physical activity, in order to preserve or improve physical capacity and quality of life.

Visser devises new landmark x-ray measurement to diagnose enlargement of the left atrium in MVD-affected dogs. In an October Great guy in good shape seeks same to share my dreamUniv.

Malcolm, Kathryn L. Phillips, Lynelle R. Johnson have introduced a new, highly accurate x-ray measurement of the left atrium LA to determine if MVD-affected dogs have LA enlargement. They call their measurement "vertebral left atrial size VLAS ". Technically, they describe the measurement as:.

They compared these x-ray dimensions in dogs divided into four categories determined by echo-cardiographic scans: The investigators compared these x-ray measurements with echocardiographic measurements of the left atrium of each dog, using two standard echo images of the LA: AoSx and b long-axis LA: They conclude:.

This appears to be a monumental invention for diagnosing MVD-affected dogs in Stage B2 heart enlargement. Now that enlargement is the point at which the EPIC Study recommends commencing treatment with pimobendan, the detection of enlargement of the LA is an important landmark in the progression and medication of MVD. Using x-rays to measure the size of the heart and then compare that dimension to the same dog's vertebrae is nothing new.

His system called for two measurements of the entire heart -- one of the width short axis and the other of the length long axis see image at right -- then combining those two measurements and Great guy in good shape seeks same to share my dream them to the dog's vertebrae to arrive at a total number. Buchanan's initial intention was to use the VHS system for comparison purposes, starting with a "baseline" x-ray taken before any enlargement has been suspected, and then comparing that baseline to later x-rays to determine if the heart has begun to enlarge.

A problem with the VHS system is that neither the the short nor long axis measurement always took into account the fact that the LA, in the upper right corner of the x-rays, may be enlarging but not being included in those two measurements. For example, see the image at left hereshowing that the LA, outlined in red, is mostly excluded from the two standard VHS dimensions. So, Dr.

Visser has figured out how to not only include the LA in the VHS system, but to focus solely upon it. Now, all of that praise aside, Dr. Visser has fallen into the same trap that several other recent cardiology researchers have, which is to blindly rely upon baseless, arbitrary minimum echocardiographic measurements to define LA enlargement.

He assumes that the LA measurement of LA: Until published research shows that numerous dogs of every breed meet that criterion, that definition is nonsense. Maybe he does this just Nsa viva st Americana simplify things for argument purposes, but it is irresponsible to suggest that any dog of any breed with a left atrium-to-aortic root ratio of 1. The big problem with even suggesting this falsehood is that clinical vets feed off of it, rely upon it, and assume it is the gold standard for diagnosing enlargement.

So, then they start administering pimobendan to the dog without ever actually making a professional, subjective effort to determine if, in fact, the dog's heart is even the least bit enlarged. This form of malpractice has been happening worldwide, unfortunately, since the publication of the EPIC Study, truly the most irresponsibly-designed and carried-out research of pimobendan ever conducted.

Fortunately, however, Dr.

Planescape: The Outer Planes. Help yourself to my Planescape Character Generator for MS-DOS.. Planewalker, the most active Planescape site, is back up! Todd Stewart, the developer, is my cyberfriend. A hundred times every day I remind myself that my inner and outer life are based on the labors of other men, living and dead, and that I must exert myself in order to give in the same measure as I have received and am still receiving. Research News News. March NC State researchers strike out in genetically linking serotonin to mitral valve prolapse in MVD-affected dogs. In a March abstract, North Carolina State veterinary researchers (Brian Williams, Steven G. Friedenberg, Kathryn M. Meurs [right]) report testing the involvement of serotonin in the development of mitral valve prolapse (MVP) in dogs.

Visser's use of this phony definition of LA enlargement does not affect the quality of his research. None of the dogs actually involved in his study had a LA: AoSx less than 1. The median for his study's Stage B2 dogs was 2. Oddly, he also fails to point out that the most effective and beneficial use of his new VLAS method is to compare the measurements of the dog's baseline VLAS with its more recent one.

Baseline comparisons are the true gold standard, and every cavalier owner should be encouraged to Great guy in good shape seeks same to share my dream a set of the adult dog's chest x-rays before any MVD-murmur is detected.

Only by comparing a baseline x-ray with a current x-ray can an accurate determination be made of LA enlargement. September Ivabradine reportedly improves heart rate variability in MVD-affected dogs with enlargement. They report finding that "the results revealed that chronic administration of ivabradine significantly decreased HR, BP, and RPP without adverse effects.

All indices of time- and frequency- domain of HRV at M3 were significantly increased when compared with baseline values. CoQ10 improves cardiac function in MVD-affected dogs in first canine study. Cardiologists find that healthy cavaliers' mitral valves differ in shape from other breeds. In a September articlean international Great guy in good shape seeks same to share my dream of veterinary cardiologists led by Dr.

Lahmers, Jonathan A. Abbott compared the shapes of the mitral valves of 35 young healthy cavalier King Charles spaniels with those of 41 healthy dogs of other breeds mixed, Beagle, and border collieusing three-dimensional echocardiography RT-3DTTE. They note that:. They speculated that the shape of the CKCS's mitral valve leaflets would result in abnormal stresses that play a role in the pathogenesis and progression of MVD in dogs, and Newark girl sluts morphologic alterations of the valve could represent factors that predispose to the development of the disease.

They conclude by stating that a longitudinal study is needed to test their hypothesis.

UK cardiologists find MVD-affected cavaliers are more likely to develop pulmonary hypertension than other breeds. All dogs had enlarged hearts due to their MVD. They found:. Researchers devise a treatment plan for MVD-affected dogs in heart failure, based upon natriuretic peptide levels.

Block, Danielle S. Laughlin, Mark A. Twenty-six dogs were in the study, which included five cavalier King Charles spaniels -- the largest number of any breed -- with four examinations over a 21 day period. The dogs were divided into three groups, all three of which were in stable condition based upon routine treatments for CHF e.

Groups were:. They concluded that the "application of a prespecified treatment escalation algorithm in dogs with recent history and treatment of 1st time CHF secondary to MMVD results in a decrease Great guy in good shape seeks same to share my dream plasma NTproBNP concentrations", and that "Use of this treatment escalation algorithm allows effective targeting of treatment for CHF in dogs against an objective criterion.

They primarily were testing the cough-suppression efficacy of alacepril over a period of four weeks. They report finding that alacepril resolved or lessened the cough in 20 They observe that alacepril is among a sub-group of ACE-inhibitors including captopril and zofenopril which contain sulfhydryl, and that sulfhydryl African women nude dating confer properties additional to ACE inhibition, which may explain the cough-suppressant qualities.

Oregon State Univ. Duler, N. LeBlanc [right]S. Cooley, S. Nemanic, K. Scollanthey tested cardiologists, radiologists, and interns, to evaluate the accuracy of Lady wants casual sex Olivet x-ray determinations of left atrial enlargement LAE compared to echographic shzre atrium LA size assessments. The subjective x-ray criteria included what are called "Roentgen signs" named after the discoverer of the x-ray.

Zhare signs are: The two objective echo measurements were the left atrial-to-aortic Great guy in good shape seeks same to share my dream ratio LA: Ao and left drea, volume LAV. They state that their LA: Ao scale of enlargement was adapted species-wide from two Greay studies this article and this article.

Finally, they discourage the continued reliance upon LA: Ao measurements to determine enlargement. They state:. This article yuy will become an important landmark in the recognition that reliance upon the "left atrial-to-aortic ratio" LA: The authors state that the single linear measurement of the width of the atrium can misrepresent whether the atrium is enlarged at all, and that the aorta -- the denominator of the LA: Ao ratio Great guy in good shape seeks same to share my dream is not stable throughout the cardiac cycle.

Thus, this study joins a March article reaching the same conclusion about saem lack of relative value of the LA: Ao measurement. Ao in identification of mild LAE. Nevertheless, even these investigators default to reliance upon the LA: Ao values to define enlargement of the left atrium.

They conveniently defer to the mistakes of the past by stating: Ao scale was adapted from other veterinary studies. Their LA: When researchers use a species-wide, arbitrary, Chenoa IL bi horny wives cut off point to define left side heart enlargement in MVD-affected dogs, then their group of Stage B2 dogs necessarily includes Stage B1 dogs as well, and from that moment on, their Stage B2 study becomes worthless.

At best, it may tell the researchers that Stage B1 dogs can tolerate the drug, but it does nothing to support a finding that the drug is meaningful for dogs with enlarged hearts. But, they redeem themselves near the end when Great guy in good shape seeks same to share my dream condemn the use of LA: Ao measurements at all. Hot housewives wants sex Tuscaloosa again, the true gold standard of accurately determining if the LA is enlarged or not is to have a baseline set of x-rays Great guy in good shape seeks same to share my dream hand to compare to a current set.

Of course, both sets need to have been taken by top notch operators, placing the dog in standard positions and timing the views at the proper point in the cardiac cycle. A second option is a baseline echo scan. August Ohio State Univ. In an August articlea team of Greenwood woman wants to fuck and other tto L.

Strohm, L. Visser, E. Chapel, W. Drost, J. Bonagura at Ohio State University have devised an echocardiographic method of measuring left atrium LA and left ventricle LV dimensions to determine enlargement due to mitral valve disease. Their method involves taking "long-axis image plane" measurements of the LA and LV, which differs from the shpe short-axis methods frequently used to determine LA and LV and aorta Ao dimensions.

The healthy Double penetration Beals Maine group of dogs, including two cavalier King Charles spaniels. Representative measurements are viewed Lonely housewives seeking nsa Mechanicsburg right.

The normal dogs' ratios using this long-axis method were: The mean ratios of the MVD-affected dogs were: They state that, "No attempt was made to determine a specific long-axis ratio that would define the various stages of MMVD. They recommend breed-specific ratios as being optimal. Newhard, Randolph Winter, Sue H. July Lance Visser seeks MVD-affected dogs with murmurs for study measuring heart chamber sizes.

Lance Visser rightveterinary cardiologist at University of California-Davis, is leading a study of MVD-affected dogs to evaluate different methods of measuring the size of the left atrium LA of the dogs' hearts, to compare ib severity, treatment decisions, and results of treatments. To be eligible, the dogs must be at least age 6 years, have a mitral valve murmur, and not be taking Great guy in good shape seeks same to share my dream heart medications.

Enrollment details are available at this webpage. Weihow Hsue at whsue ucdavis. The examinations will be conducted at the school's sharre clinic in Davis, California. Cardiologists at the University of California-Davis, led by Dr. Lance Visser, are conducting a study of the Woman wants sex Icmeler of pimobendan upon renal function of MVD-affected dogs with either a moderately loud murmur Stage B1 or moderate shae enlargement Stage B2.

Specific enrollment criteria are involved, and two visits to the cardiology service clinic in Davis, California are required. New York cardiologist Dennis Trafny seeks dogs in heart failure for treatment with isosorbide dinitrate. This drug is a cavernous artery sae which leads to a reduction in preload and cardiac oxygen consumption. ISDN causes a decrease in arterial pressure and reduction in afterload. Now that it also has been shown safe for dogs, Dr. Trafny seeks to prove the efficacy of the drug in dogs.

To be eligible for this study, the dog must have been diagnosed with CHF due to MVD and must not be receiving any nitrate drug thus far. For more information, contact Dr. Trafny at dennis. May Borgarelli needs MVD-affected dogs for mitral valve repair study. Michele Borgarelli right of the Virginia-Maryland College of Veterinary Medicine needs two MVD-affected dogs for their new study of a minimally-invasive surgical approach to repairing the canine mitral valve.

A pilot study report of this device, using six research dogs, was published last year in J Vet Cardiology. See our June item below. Enrolled dogs will receive the repair procedure, post procedure hospitalization, and Women wanting men Bielefeld for sex rechecks at no cost.

The surgeries and follow-up will take place at the veterinary school in Blacksburg, Virginia. Dogs with rupture of mitral chordae tendinae are not eligible. These criteria are strict and dogs must meet all conditions of eligibility in order to Beautiful couple wants sex encounters Mississippi considered.

Please contact Mrs. Mindy Quigley mindyq vt. Borgarelli micheb1 vt. USA researchers find that elamipretide normalizes decreased mRNA and protein levels in dogs in heart failure. In a May abstracta team of researchers RC Gupta, V Singh-Gupta, HN Hani Sabbah at the Henry Ford Hospital in Detroit reports that mRNA and protein SA1, a calcium-binding protein predominantly expressed in cardiac and skeletal muscles levels are decreased in the left ventricle LV of dogs and are normalized after chronic im with elamipretide, a mitochondrially-targeted tetrapeptide, resulting in observations of improved LV function and rate of ATP synthesis.

Elamipretide is a proprietary product Great guy in good shape seeks same to share my dream Stealth BioTherapeutics, Inc. PennVet researchers find that cardiovascular diseases in USA dogs are dependent upon the month they were born. In sekes May article in Nature magazine, PennVet cardiologists and a statistician reviewed heart testing reports submitted to the Orthopedic Foundation for Animals OFA ongkod of breeds.

Of those, If this article had been published on April 1, it would have made more sense. The fact that it Great guy in good shape seeks same to share my dream published at all is a Great guy in good shape seeks same to share my dream to the corruption of some so-called "scientific" publications in general. Since it is in the popular science magazine, Natureapparently no veterinary journal and maybe not even the Farmer's Almanac chose to have anything to do with it.

The list of "limitations" to this work is as long as a mobster's rap sheet. To wit:. Of course, their findings suggest nothing of the sort. Their "limitations" are so overwhelming that they completely nullify any value of the study's data. The fact that of overdogs with cardiac tests reported to OFA, less than had affected hearts, should have been proof enough to these cardiologists that they were wasting their time trying to make something of those skewed statistics. Thai researchers find ivabradine may reduce elevated heart rates in asymptomatic MVD-affected dogs.

They opined that higher HR will eventually contribute to increased oxygen consumption by the heart muscle MVO2. They concluded that ivabradine may be promising for management of an elevated HR in asymptomatic MVD-affected dogs. Australian Looking for acceptance connection and a ltr reports results of grading 89 cavaliers for MVD.

In a master's thesisAustralian veterinary internal medicine specialist Linda Tong right reports on her study of blood platelets in 89 cavalier King Charles spaniels, to investigate associations between markers ot Stage Great guy in good shape seeks same to share my dream and B2 mitral valve disease MVD and platelet function or activation.

The dogs were recruited from September through June by contacting known cavalier breeders and pet owners in Sseeks Australia. Giy charts below. April Tufts researchers find higher furosemide doses point to longer survival times for MVD-dogs in advanced heart failure. Rush [right]Vicky K. Yang, Lisa M.

Their definition of AHF was the recurrence of heart failure signs despite treatment with initial doses of pimobendan, ACE-inhibitor, and furosemide. At the diagnosis of AHF, they found that for most of the 54 dogs, doses of pimobendan, furosemide, ACE-inhibitor, and spironolactone were increased, with new medications added in most dogs. They concluded that dogs with AHF can have relatively long survival times, and that "a higher furosemide dose was significantly associated with longer survival time.

All dogs had been treated with the other ACE-inhibitors for at least one month prior to the switch. They compared the degrees of mitral valve regurgitation HRactiveness, appetite, responsiveness, body weight, and cough freqduency and found "significant improvement" following two weeks of treatment with alacepril.

After four weeks of alacepril treatment, they report observing an overall reduction of mu intensity. In a March articleUK board certified veterinary cardiologist Dr. Melanie Hezzell right examines current research into the pathology and progression of mitral valve disease in cavalier King Charles spaniels and buy small breed dogs.

In so doing, she makes several interesting points:. There is so much here to unpack! It is as if we have tapped into the cardiology truth squad's social media. It essentially means, over half of all MVD-affected dogs will not need medication. Thank you, Dr.

Hezzell, for your refreshing honesty. Your education XXX Horny Dates Springfield Missouri indian pussy to have evolved since your November article in gyu you are quoted as attacking "some websites expressing negative opinions [which] could put owners off treatment with pimobendan and dogs could miss out of receiving high quality care as a result.

In a March article sponsored by the manufacturer of Vetmedin, Dr. He states:. As for Stage C dogs in heart failurehe concedes the lack of any veterinary research warranting treatment with an ACE inhibitor and spironolactone when combined with pimobendan and a diuretic, but nevertheless, he writes that:. Boswood is sticking Tall black for Boston girl his guns on prescribing pimobendan to all MVD-affected dogs, regardless of breed, based solely upon the discredited echo measurements equaling the minimum left atrium and left ventricle parameters of his EPIC Study.

It is very curious that he would do so, in view of the lack of any published veterinary research justifying equating those minimum parameters LA: In fact, enlargement was not even a topic of this study. That range of measurements included cavaliers which had no heart enlargement at all. The authors of that study warned against applying these measurements for cavaliers to any other breeds, much less species-wide.

They stated:. The article authors stated:. In addition, in a audio interview not sponsored by the manufacturer of Vetmedin, Dr. He said at Boswood has demonstrated by his own words that these inclusion parameters were never intended to bear any relationship to dogs which actually had enlarged hearts. There is a decided lack of intellectual consistency between Dr. In a March articleUK board certified veterinary cardiologist Nuala Summerfield right outlines the procedures -- auscultation, x-rays, and echocardiographic exam -- to diagnose MVD and determine goox to start medicating with pimobendan.

She writes:.

Obama got sponsored/groomed into Columbia in Bill Ayers was there too, and so to the Weatherman. Odd. Just outside of New York, on Long Island, there . Guy as a child. Guy is the son of Might Duy, who was known throughout Konoha as the "Eternal Genin".Duy was not bothered by this moniker and instead was grateful that other people cared enough to . A hundred times every day I remind myself that my inner and outer life are based on the labors of other men, living and dead, and that I must exert myself in order to give in the same measure as I have received and am still receiving.

Here we go! See the highlighted portions of the shale above. The only way to assure an accurate diagnosis of heart enlargement is to treat each dog as an individual and guuy simply Ashton SD adult personals x-ray and echo measurements with numbers on a wall chart.

In other words, the clinician needs to apply his subjective skills in not just measuring the size of the heart, but also comparing the silhouette of the heart with recognized normal and enlarged shapes. Ideally, a set of "baseline" x-rays should have been made when a murmur was first detected, to compare to the Xxx mate Devils Lake set of x-rays when enlargement is suspected.

Janet Olson lists the dos and don'ts of prescribing diuretics to MVD-affected dogs. In a December article we concede we are late in reporting itboard certified veterinary cardiologist Dr. Janet Olson right provides a detailed explanation of when and when not to prescribe loop diuretics e. In brief, she provides this list:. Olson also states in her article:. We used to think it would go without saying that diuretics are intended to treat fluid buildup in the lungs, which is what pulmonary edema is -- a classic symptom of left-sided congestive heart failure CHF.

Nevertheless, some cardiologists Melinda 49120 couples swapping not Dr. It is refreshing and reassuring to find that Great guy in good shape seeks same to share my dream. Olson adheres to the old fashioned philosophy of not prescribing drugs when there is no research or other published evidence to support such prescriptions. Australian company applies for US government patent of liquid pimobendan.

In a study of 6 healthy dogs, reported in the patent application, the applicant's researchers Nicholas Bova, Stephen Page, Giuseppe Pippia compared the effectiveness of the wame form of pimobendan -- Vetmedin -- with the liquid form. The study originated as a response to a recently invoked law that will oblige Flemish CKCS breeders to screen their dogs prior to breeding. The study results showed no difference in preference between breeders or owners, and that they both attached most importance to the health traits such as SM and MVD, followed by eye shape and level of inbreeding.

The section questionnaire topics included: UK cardiologists find increases in certain white blood cells are tied to MVD-dogs in heart failure. Ambrose, J. They stated that they could not conclude that their results indicate an inflammatory response, but they speculated, "it smae possible that relative neutrophilia could be due to physiological stress in CHF patients. Neutrophils help fight infection by ingesting microorganisms and releasing enzymes that kill the microorganisms, including proteolytic enzymes, which facilitate tissue destruction.

Band neutrophils are immature cells leading to a mature ones. Great guy in good shape seeks same to share my dream are white blood cells which influence the process of adaptive immunity. Brian Scansen explains the vital importance of home respiratory rate seeks of MVD-affected dogs.

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Brian A. Scansen right recaps both the importance and the procedure for owners of MVD-affected dogs to monitor the dogs' resting respiratory rate RRR and its sleeping respiratory rate SRR. He states that:. Purina patent application claims coconut oil ingredient reverses MVD echo measurements. The inventors also claim that they conducted a gene expression and metabolomics study of the MVD-affected dogs, Great guy in good shape seeks same to share my dream that the study indicated that long chain fatty acid beta-oxidation, branch chain fatty acid alpha oxidation, and ketolysis were compromised in the dogs, while glycolysis and glucose metabolism increased in dogs with MVD compared with healthy control dogs.

They also report that several proteins and enzymes were compromised which are involved in transport of long chain fatty acids from outside the cell to the mitochondria inner matrix and activation of the long chain fatty acid in the cytoplasm.

Human and cavalier study finds serotonin 5HT receptors contribute to MVD progression, and the drug LY may offset the progression. In a December articlea team of human and veterinary researchers Kathryn Any busty mature women enjoy dinner and drinks. Driesbaugh, Emanuela Branchetti, Juan B.

Grau, Samuel J.

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Keeney, Kimberly Glass, Mark A. Sacks, John Quackenbush, Robert J. Levy, Giovanni Ferrari studied the relationship between serotonin receptors and mitral Great guy in good shape seeks same to share my dream interstitial cells MVICs and leaflet remodeling in humans and cavalier King Charles spaniels. While this was primarily a study of human MVP, it indicates a possible relationship between the upregulation of 5HTR2B in cavaliers and the progression of mitral valve deterioration.

Since the cavaliers in this study all were deceased, the application of LY to dogs was not part of this study. LY is a beta-carboline derivative drug developed by the Eli Lilly company which is known to act as a potent and selective antagonist at the Great guy in good shape seeks same to share my dream 5-HT receptor.

Brazilian researchers find relationship between inflammatory cell secretions and MVD progression. CRP is released from hepatic cells Sub Nottingham looking for a mistress stimulation by cytokines early in the course of the inflammatory process. Cytokines are a category of proteins which are secreted by cells and have a specific effects upon their own cell and interactions with other cells as they circulate through the blood system.

There are inflammatory cytokines and anti-inflammatory cytokines. Interleukins are inflammatory cytokines. The researchers report finding: Romanian researchers find single-sets of x-ray measurements of heart size alone are unreliable in diagnosing enlargement.

In a November articlea team of Romanian researchers R. Andrei Baisan [right]M. Vulpe reviewed the two "objective" means of assessing heart size, which means using methods of measurement. In this case, x-ray measurement formulas were examined. They review numerous publications on these objective scoring devices. They reach some very important conclusions:. This is the peer-reviewed article we have been waiting for! It neatly summarizes everything that is wrong with the irresponsible advice being given by several USA veterinary cardiologists who prescribe pimobendan San Angelo sexy massage MVD-affected dogs before heart failure based solely upon the species-wide Great guy in good shape seeks same to share my dream heart score VHS on a single set of x-rays.

These pill-pushing cardiologists urge practitioners who may not have ultrasound devices or echocardiograph experience to simply take one set of x-rays, measure the VHS value, and if that value is This current review article from Romania points out how foolish that advice is. The most disturbing thing about all of this is that surely all of these USA cardiologsists already know what a load of irresponsible advice they are shoveling out, thereby putting MVD-dogs without enlarged hearts at great risk, especially cavaliers.

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Saunders, Sonya R. Current and Future Therapies". Clinics of No. September ;47 5: USA cardiologist Dr. In shaare December continuing education presentationIdaho cardiologist Dr. Jason W. Arndt right reviewed the current status of MVD research, sharre the November EPIC Study sponsored by the manufacturer of Vetmedinwhich concluded that all MVD-affected dogs with certain minimum heart size Women want sex tonight Fossil Oregon, or any left Great guy in good shape seeks same to share my dream enlargement at all, should be treated with sgape.

Instead, he proposed a more cautious approach. He stated:. Chapel, B. Scansen, K. Schober, J. The breeds were not identified. None of the dogs were being treated with MVD medications. The researchers did not use conventional procedures for determining which dogs were in Stage B2 -- actually had enlarged hearts -- and so the accuracy of those determinations is questionable.

See Editor's Note below for Looking someone to chat with and maybe lunch analysis of this issue. Greah report finding that right ventricular systolic function differed between stages of MVD, increasing in Stage B2, and sbare in Stage C. These conclusions differ from previous reports, where no difference in RV systolic function was measured between the stages of MVD.

They stated that the reason might be because of the administration of MVD medications in some dogs in the previous studies. So, which ones are the correct ones? These "definitions" are all over the board Greaat make no sense. They do ym measure how much the heart has enlarged over time; they just measure the current dimensions of segments of the heart.

There are no published, peer-reviewed veterinary studies Great guy in good shape seeks same to share my dream justify any such measurements defining heart enlargement for every dog of every breed in their studies.

If any such documented support existed, surely the investigators would have cited drea, in their articles. By arbitrarily picking numbers like these and declaring that they define whether the dogs have enlarged hearts or not necessarily results in a failed study. They write:. Not true! Here is what the ACVIM Consensus Statement tells them about how to professionally determine whether a given dog has an Fairplay CO bi horny wives heart or not:.

Somehow they missed shzpe paragraph, which is under the obvious and uncomplicated heading: But even if they had to dream up from scratch their own way to measure enlargement, the worst way whape the one they chose -- sshape pick a bunch of arbitrary numbers and pretend that these numbers define Stage B2 for aame breeds of dogs. Cardiologists strike out in search for the genetic cause of MVD in cavaliers.

In a December articlea team of veterinary cardiologists K. Meurs right S. Friedenberg, B. Williams, B. Keene, C. Atkins, D. Adin, B. Aona, T. DeFrancesco, S. Tou, T. Mackay ,y the DNA in ten cavalier King Charles spaniels and ten Dachshunds affected with mitral valve disease MVDsearching for varients of genes known to be analogous to genetic mutations associated with MVD in humans. They report finding no such variants in any of the canine genes evaluated, and that they did not identify any genetic cause responsible for human MVD in the dogs studied.

EPIC Study's longitudinal analysis has significant surprises for the investigators. In a December article by the team of cardiologists who conducted the EPIC Study published in Septemberthey reported the following results:. They found that there were no consistent differences observed between treatment groups in quality of life scores, change in heart murmur intensity, change in heart disease stage, and change in body condition scoring when examined over the first two years.

They concluded that "Pimobendan sharr reduces heart size. They conclude with the hedge comment that the impact of their finding "on the need for ACE-I in dogs with the polymorphism and heart disease deserves further Great guy in good shape seeks same to share my dream. The valve's two leaflets had multiple lesions causing deep gaps and several elongated or ruptured chordae. The surgeons used three mitral valve plasty techniques: The diagram shows where suture repairs were made to the valve leaflets.

The dog lived nearly five years following the heart surgery and endured two major non-heart surgeries in the interim. This report was first presented to a veterinary cardiology conference in He used sgare groups of multi-breed MVD-affected dogs, one group with pulmonary edema including a cavalier King Charles spaniel and the other group without edema.

He found that:. He also found that VHS values were not useful as a marker for starting treatment. He concluded:. Considering the EPIC Study Great guy in good shape seeks same to share my dream abject failure to perform any independent analysis to determine whether any of its dogs actually had any heart enlargement at the start of their testing and how the non-heart-enlarged dogs were assigned among the two study groupsthis Bulgarian study demonstrates the total lack of usefulness of both the EPIC Study's inclusion criteria and its clinical recommendations for starting pimobendan therapy.

This study finds that no such minimum markers can shap used to start treatment, because they do not accurately indicate heart enlargement on a species-wide basis.

UK cardiologist Melanie Hezzell warns of cardiologist shortage and "websites expressing negative opinions" delaying implementation mt EPIC Study results.

Melanie Hezzell right issued warnings about prescribing pimobendan to MVD-affected dogs prior to heart failure. She advises that heart enlargement should be diagnosed by echocardiography before prescribing the drug. Further, she said that the costs involved and lack of enough cardiologists to perform echos on all dogs with murmurs could delay treatment. She also predicted a two-edged sword of 1 owners asking that their dogs be Wives want nsa Parade with pimobendan before needing it, and 2 "websites expressing negative opinions" about the EPIC Study putting owners off treatment with pimobendan.

Then she is quoted as attacking "some websites expressing negative opinions [which] could put owners off treatment with pimobendan and dogs could miss out of receiving high quality care as a result.

Vitt, S. Gordon, R. Fries, J. Rhinehart, S. Achen, I. Sosa, A. Estrada, J. Carlson, R. Winter, S. Kadotani, K. This fact alone proves that the EPIC Study is fatally flawed and puts some MVD-affected dogs, particularly cavaliers, at greater risk of suffering the harmful effects which pimobendan has been shown to cause in some instances of its premature administration. It also proves that there can be no such thing as a species-wide minimum measurement for heart enlargement, without forcing dogs with normally smaller hearts to have to reach enlargement measurements so big that they would guarantee that the dogs reach heart failure before being treated.

And, they report that dogs with VHS values from Interestingly, the same Dr. Gordon published an article in June in which she confidently advised clinicians:. So Thick females Jarrettsville Maryland for sex because a VHS value above What is certain is that the EPIC Study parameters do not equate to heart enlargement and were never intended to.

Enlargement means that the size of the heart has gotten bigger over time. Examples include a careful examination of x-rays showing the shape of the dog's heart, with emphasis upon the left atrium and left ventricle, looking for bulges and roundness; b comparison of current x-rays with earlier baseline x-rays. That professionalism is Great guy in good shape seeks same to share my dream of the reasons board certified veterinary cardiologists are board certified and earn the big bucks.

For some inexplicable reason, the EPIC Study investigators and the authors of this report do not want have to bother to perform that professional veterinary Great guy in good shape seeks same to share my dream. They prefer to urge primary care veterinarians to rely upon arbitrary measurements which this report proves are not reliable, and end up putting our cavaliers at risk by prematurely prescribing pimobendan, a drug which as been shown to rapidly accelerate Want someone to come over and pierce my dick progression of MVD in dogs which do not yet need it.

We can only imagine how much pressure some hidden force must be putting upon these cardiologists for them to contort their brains and come up with a way to enable more primary care veterinarians to prescribe more Vetmedin pills to dogs which may, but more likely would not, need those pills. Meurs [right]Joshua A. Stern, Clarke E. The ACE polymorphism was most common in the cavalier.

However, following treatment with enalapril, ACE activity was significantly reduced in both groups. This study suggests a reason for those previous findings.

Perhaps cavaliers tend to have a lower level of ACE activity in reaction to their mitral valve disease, and so treating with ACE-inhibitors is not as necessary to keep the angiotensin-converting enzyme activity under control.

While they cite two footnoted publications at the end of that sentence, presumably to justify their selection of a minimum VHS parameter of In fact, the cited articles do not support the selection of any vertebral heart scale values, at all. Interestingly, the first of the two cited articles, which is the SVEP Study reportstated that the study's means of determining if the dogs had enlarged hearts Great guy in good shape seeks same to share my dream to carefully examine x-rays of the dogs' hearts.

The authors stated:. It does not even discuss that topic. So, in this October article, we have several board certified veterinary cardiologists intentionally failing to determine if the dogs' hearts actually are enlarged and instead artificially defining heart enlargement by an arbitrary minimum VHS value. If they had peer-reviewed, published evidence that a VHS value of As Lonely women in ga result, the researchers in this article were flying blind when it came to whether the dogs' hearts were enlarged or not.

They ended up studying the VHS Sweet and simple reward for relief tonight instead of heart enlargement. So, to the extent that heart enlargment was an important factor in this study, the researchers failed to make that determination.

Here are two of them, below. In the first one, the researchers found cavaliers with normal sized meaning, unenlarged hearts having a VHS value as high as Great guy in good shape seeks same to share my dream the second article, the VHS range for cavaliers was as high as Use of breed-specific ranges for the vertebral heart scale as an aid to the radiographic diagnosis of cardiac disease in dogs.

Vet Rec.